Exploring Non-Fouling Membrane Materials for Cell Culture Filtration
Keywords:
Non-Fouling Membranes, Membrane Biofouling, Surface Modification, Protein Resistance, Hydrophilic Polymers, Cell Culture Filtration, Biopharmaceuticals.Abstract
The past few years have been marked by the decrease in the efficiency of protein separation
processes in biopharmaceutical systems and the automated fabrication of biopharmaceuticals in closed
controlled volumetric bioreactors. This paper provides a comprehensive approach for the development and
use of non-fouling membrane materials for cell culture filtration used in biopharmaceutical processes. This is
done through the incorporation of advanced hydrophilic polymers as surface modifications alongwith
nanostructured membranes that provide improved resistance to protein and cell adhesion. This paper
examines recent literature, explains system design optimization, and analyzes comparative performance with
alternative membranes. Results add to the body of knowledge pertaining to automation-ready, scalable
biomanufacturing systems that effectively achieve improved permeability, enhanced resistance to fouling,
extended filtration life, and optimized sterile operational conditions.
