Membrane Filtration in Continuous Pharmaceutical Manufacturing: Challenges and Solutions
Keywords:
Membrane Filtration, Biotechnology, Biopharmaceuticals, Filter Performance, Process Optimization, Selectivity, Fouling Control, Continuous Pharmaceutical Manufacturing, Hybrid Modeling.Abstract
The use of membrane filtration in the context of continuous pharmaceutical manufacturing (CPM)
has been studied with relation to process steps filtering and drug purification (unit operations). Key
challenges of operation are identified and effective solutions proposed. Process conditions and membranes
were tested empirically and modeled for membrane performance to achieve results. Results suggest that
process efficiency hinges on resistance to fouling, selectivity, and membrane integrity. Significant
improvements to filtration reliability and drug purity could be achieved by adjusting the membrane material
selection and the operational parameters. Greater attention ought to be directed towards the integration of
intelligent control systems with membranes, as this would enable more precise and differentiated robust and
scaleable methods CPM.
