Advanced Nanofiber Filters for Sterile Filtration in Biopharmaceutical Processes

Abstract

This research examines the design and application of novel nanofiber filters in the context of
sterile filtration processes within biopharmaceutical production. Nanofiber filters made from electrospinning
techniques and advanced material formulations show higher microbial retention and flow efficiency than
traditional membranes. The work incorporates experimental data with hybrid modeling approaches to
simulate performance under aseptic conditions. The results show improved filtration efficiency, structural
integrity, and process scalability which indicate these materials are suitable for continuous and sterile
pharmaceutical manufacturing.